A new study published in the Journal of Virology showed that non-steroidal anti-inflammatory drugs like ibuprofen and naproxen reduce antibody and inflammatory responses to the coronavirus in mice. People often use these common over-the-counter medications for mild cold and flu symptoms, in addition to many other illnesses and injuries. This research suggests that depending on when you take these drugs during a COVID-19 infection, the result could be very different. They might be detrimental early in the course of infection, while they could be helpful in later, more serious cases marked by severe inflammation. We need studies on these drugs for COVID-19 in humans. But it also suggests NSAIDs might interfere with the vaccine. Although these drugs could decrease vaccine side effects, in theory at least, they could decrease your immune response, making the vaccine less effective.