New research shows that exercise literally becomes harder to do the less often you do it – and offers an explanation why. In a study published in the Journal of Clinical Investigation, researchers at the University of Leeds discovered that low levels of physical activity lead to the deactivation of a vital protein in the body called Piezo1. Deactivation of this protein decreases the density of capillaries carrying blood to the muscles, reducing blood flow to the muscles. Physical activity and exercise then become much more difficult. This study suggests that regular exercise can keep our Piezo1 protein active and improve our physical performance and health.